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This effect is given by catching the Corprus disease. When included in a spell with other effects, it causes some of the other effects to strengthen over time. On its own, it does not actually do anything (possible exceptions in the Bugs section) - the actual effects of Corprus are represented by their respective effects, like any disease.
After contracting corprus as part of the Main Quest, it will be accompanied by several Drain Attribute effects which will lower your Willpower, Intelligence, Personality and Speed, as well as Fortify Attribute effects which will raise your Strength and Endurance. These effects all start off this a magnitude of 1, but will increase in magnitude over time until you cure yourself.
This effect also exists to control the way that NPCs react to you (i.e. with fear and disgust) when you are infected with the disease. The only way to acquire this effect is to catch the disease during the Sixth House Base quest during the Main Quest (which is completely unavoidable), and the only way to get rid of it is to complete the Corprus Cure quest immediately afterwards.
- Tanusea Veloth in the Arena Pit of Vivec has Corprus Disease, which you can contract by searching her corpse. However, this will prevent you from completing the Main Quest, since Divayth Fyr will be unable to cure you.
- Despite what Divayth Fyr says about Corprus making its victims immune to other diseases (see Corprus Cure journal index 20), it is still possible to contract other diseases while afflicted with Corprus. You only receive immunities to disease after drinking Divayth Fyr's potion.
- It is possible to acquire a corprus spell when fighting Senise Thindo. However, the corprus effect doesn't actually give you the disease, or any effects of it, but may crash the game.
- Fighting, or searching the corpse of, NPCs with spells with the Corprus effect might add the spell to the player's spell list, or cause other odd behavior.
Also see the talk page.